7jh0
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Crystallographic structure of glyceraldehyde-3-phosphate dehydrogenase from Schistosoma mansoni== |
| - | <StructureSection load='7jh0' size='340' side='right'caption='[[7jh0]]' scene=''> | + | <StructureSection load='7jh0' size='340' side='right'caption='[[7jh0]], [[Resolution|resolution]] 2.51Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7jh0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JH0 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jh0 OCA], [https://pdbe.org/7jh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jh0 RCSB], [https://www.ebi.ac.uk/pdbsum/7jh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jh0 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=CSP:S-PHOSPHOCYSTEINE'>CSP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jh0 OCA], [https://pdbe.org/7jh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jh0 RCSB], [https://www.ebi.ac.uk/pdbsum/7jh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jh0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/G3P_SCHMA G3P_SCHMA] This antigen is associated with human resistance to schistosomiasis. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The enzyme Glyceraldehyde-3-Phosphate Dehydrogenase from Schistosoma mansoni (SmGAPDH) is characterized as a therapeutical target for schistosomiasis. In this context, we report here the experimental structure, structural analyses and comparisons of SmGAPDH, the first one from a Platyhelminth. The enzyme was expressed, purified and assayed for crystallization, what allowed the obtainment of crystals of sufficient quality to collect X-ray diffraction data up to 2.51 A resolution. SmGAPDH is the only GAPDH to present the sequence NNR (its residues 114-116) which leads to (especially R116) a hydrogen bond network that possibly reflects on the flexibility of residues to interact with the adenine part of NAD(+), speculated to be important for differential drug design. | ||
| + | |||
| + | Structure determination and analyses of the GAPDH from the parasite Schistosoma mansoni, the first one from a platyhelminth.,Boreiko S, Silva M, Iulek J Biochimie. 2021 May;184:18-25. doi: 10.1016/j.biochi.2021.01.014. Epub 2021 Jan , 30. PMID:33524435<ref>PMID:33524435</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7jh0" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Glyceraldehyde-3-phosphate dehydrogenase 3D structures|Glyceraldehyde-3-phosphate dehydrogenase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Schistosoma mansoni]] |
| + | [[Category: Boreiko S]] | ||
| + | [[Category: Iulek J]] | ||
| + | [[Category: Silva M]] | ||
Current revision
Crystallographic structure of glyceraldehyde-3-phosphate dehydrogenase from Schistosoma mansoni
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