7jzr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:15, 18 October 2023) (edit) (undo)
 
Line 1: Line 1:
-
====
+
==CFTR Associated Ligand (CAL) PDZ domain bound to peptidomimetic LyCALAEB==
-
<StructureSection load='7jzr' size='340' side='right'caption='[[7jzr]]' scene=''>
+
<StructureSection load='7jzr' size='340' side='right'caption='[[7jzr]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[7jzr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JZR FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jzr OCA], [https://pdbe.org/7jzr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jzr RCSB], [https://www.ebi.ac.uk/pdbsum/7jzr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jzr ProSAT]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VU4:4-(2-aminoethyl)benzoic+acid'>VU4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jzr OCA], [https://pdbe.org/7jzr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jzr RCSB], [https://www.ebi.ac.uk/pdbsum/7jzr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jzr ProSAT]</span></td></tr>
</table>
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>
 +
== References ==
 +
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Z-disk]]
+
[[Category: Synthetic construct]]
 +
[[Category: Gill NP]]
 +
[[Category: Madden DR]]

Current revision

CFTR Associated Ligand (CAL) PDZ domain bound to peptidomimetic LyCALAEB

PDB ID 7jzr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7jzr"
Personal tools