7kh8

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Current revision (15:24, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7kh8' size='340' side='right'caption='[[7kh8]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='7kh8' size='340' side='right'caption='[[7kh8]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7kh8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KH8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7kh8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KH8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=WE7:3-[(2,6-dichlorophenyl)methyl]-8-(2-methylphenyl)-3H-purin-6-amine'>WE7</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=WE7:3-[(2,6-dichlorophenyl)methyl]-8-(2-methylphenyl)-3H-purin-6-amine'>WE7</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kh8 OCA], [https://pdbe.org/7kh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kh8 RCSB], [https://www.ebi.ac.uk/pdbsum/7kh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kh8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kh8 OCA], [https://pdbe.org/7kh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kh8 RCSB], [https://www.ebi.ac.uk/pdbsum/7kh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kh8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PPAC_HUMAN PPAC_HUMAN]] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
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[https://www.uniprot.org/uniprot/PPAC_HUMAN PPAC_HUMAN] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7kh8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7kh8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ardecky, R J]]
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[[Category: Ardecky RJ]]
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[[Category: Bottini, N]]
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[[Category: Bottini N]]
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[[Category: Chung, T D.Y]]
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[[Category: Chung TDY]]
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[[Category: Diaz, M A]]
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[[Category: Diaz MA]]
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[[Category: Hedrick, M P]]
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[[Category: Hedrick MP]]
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[[Category: Holmes, Z J]]
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[[Category: Holmes ZJ]]
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[[Category: Jackson, M R]]
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[[Category: Jackson MR]]
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[[Category: Pinkerton, A B]]
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[[Category: Pinkerton AB]]
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[[Category: Rodiles, S]]
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[[Category: Rodiles S]]
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[[Category: Roosild, T]]
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[[Category: Roosild T]]
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[[Category: Santelli, E]]
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[[Category: Santelli E]]
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[[Category: Stanford, S M]]
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[[Category: Stanford SM]]
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[[Category: Zou, J]]
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[[Category: Zou J]]
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[[Category: Complex]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inhibitor]]
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[[Category: Lmwptp]]
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[[Category: Protein tyrosine phosphatase]]
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Current revision

Human LMPTP in complex with inhibitor

PDB ID 7kh8

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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