1nkp

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[[Image:1nkp.gif|left|200px]]
[[Image:1nkp.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1nkp |SIZE=350|CAPTION= <scene name='initialview01'>1nkp</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1nkp", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= Myc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Max ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1nkp| PDB=1nkp | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nkp OCA], [http://www.ebi.ac.uk/pdbsum/1nkp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nkp RCSB]</span>
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}}
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'''Crystal structure of Myc-Max recognizing DNA'''
'''Crystal structure of Myc-Max recognizing DNA'''
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[[Category: Burley, S K.]]
[[Category: Burley, S K.]]
[[Category: Nair, S K.]]
[[Category: Nair, S K.]]
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[[Category: bhlhz]]
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[[Category: Bhlhz]]
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[[Category: dna]]
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[[Category: Dna]]
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[[Category: heterodimer]]
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[[Category: Heterodimer]]
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[[Category: oncogene]]
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[[Category: Oncogene]]
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[[Category: transcription]]
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[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:38:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:31:40 2008''
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Revision as of 23:38, 2 May 2008

Image:1nkp.gif

Template:STRUCTURE 1nkp

Crystal structure of Myc-Max recognizing DNA


Overview

X-ray structures of the basic/helix-loop-helix/leucine zipper (bHLHZ) domains of Myc-Max and Mad-Max heterodimers bound to their common DNA target (Enhancer or E box hexanucleotide, 5'-CACGTG-3') have been determined at 1.9 A and 2.0 A resolution, respectively. E box recognition by these two structurally similar transcription factor pairs determines whether a cell will divide and proliferate (Myc-Max) or differentiate and become quiescent (Mad-Max). Deregulation of Myc has been implicated in the development of many human cancers, including Burkitt's lymphoma, neuroblastomas, and small cell lung cancers. Both quasisymmetric heterodimers resemble the symmetric Max homodimer, albeit with marked structural differences in the coiled-coil leucine zipper regions that explain preferential homo- and heteromeric dimerization of these three evolutionarily related DNA-binding proteins. The Myc-Max heterodimer, but not its Mad-Max counterpart, dimerizes to form a bivalent heterotetramer, which explains how Myc can upregulate expression of genes with promoters bearing widely separated E boxes.

About this Structure

1NKP is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors., Nair SK, Burley SK, Cell. 2003 Jan 24;112(2):193-205. PMID:12553908 Page seeded by OCA on Sat May 3 02:38:53 2008

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OCA

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