1nks

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[[Image:1nks.gif|left|200px]]
[[Image:1nks.gif|left|200px]]
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{{Structure
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|PDB= 1nks |SIZE=350|CAPTION= <scene name='initialview01'>1nks</scene>, resolution 2.57&Aring;
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The line below this paragraph, containing "STRUCTURE_1nks", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1nks| PDB=1nks | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nks OCA], [http://www.ebi.ac.uk/pdbsum/1nks PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nks RCSB]</span>
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}}
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'''ADENYLATE KINASE FROM SULFOLOBUS ACIDOCALDARIUS'''
'''ADENYLATE KINASE FROM SULFOLOBUS ACIDOCALDARIUS'''
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[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
[[Category: Vonrhein, C.]]
[[Category: Vonrhein, C.]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: thermophilic]]
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[[Category: Thermophilic]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:39:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:31:42 2008''
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Revision as of 23:39, 2 May 2008

Image:1nks.gif

Template:STRUCTURE 1nks

ADENYLATE KINASE FROM SULFOLOBUS ACIDOCALDARIUS


Overview

The adenylate kinase from the hyperthermophilic archaean species Sulfolobus acidocaldarius has been cloned, expressed in Escherichia coli, purified and crystallized. The crystal structure was elucidated by multiple isomorphous replacement and non-crystallographic density averaging. The structure was refined at 2.6 A (1 A=0.1 nm) resolution. The enzyme is trimeric, in contrast to previous solution measurements that suggested a dimeric structure, and in contrast to the vast majority of adenylate kinases, which are monomeric. In large parts of each subunit the chain fold resembles the known enzyme structure from eubacteria and eukaryotes although the sequence homology is negligible. Since the asymmetric unit contains two trimers with and without bound AMP at the AMP sites and with an ADP at one of the six ATP sites, the analysis shows the enzyme in several states. The conformational differences between these states resemble those of other adenylate kinases. Because of sequence homology, the structure presented provides a good model for the methanococcal adenylate kinases.

About this Structure

1NKS is a Single protein structure of sequence from Sulfolobus acidocaldarius. Full crystallographic information is available from OCA.

Reference

The structure of a trimeric archaeal adenylate kinase., Vonrhein C, Bonisch H, Schafer G, Schulz GE, J Mol Biol. 1998 Sep 11;282(1):167-79. PMID:9733648 Page seeded by OCA on Sat May 3 02:39:00 2008

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