7l8r
From Proteopedia
(Difference between revisions)
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==Crystal structure of human GPX4-U46C mutant K48A== | ==Crystal structure of human GPX4-U46C mutant K48A== | ||
| - | <StructureSection load='7l8r' size='340' side='right'caption='[[7l8r]]' scene=''> | + | <StructureSection load='7l8r' size='340' side='right'caption='[[7l8r]], [[Resolution|resolution]] 1.52Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L8R FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7l8r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L8R FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l8r OCA], [https://pdbe.org/7l8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l8r RCSB], [https://www.ebi.ac.uk/pdbsum/7l8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l8r ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.52Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l8r OCA], [https://pdbe.org/7l8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l8r RCSB], [https://www.ebi.ac.uk/pdbsum/7l8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l8r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity). | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Glutathione peroxidase|Glutathione peroxidase]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Conrad M]] | [[Category: Conrad M]] | ||
Current revision
Crystal structure of human GPX4-U46C mutant K48A
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Categories: Homo sapiens | Large Structures | Conrad M | Forouhar F | Friedman J | Liu H | Ramesh S | Saneto R | Seibt T | Shchepinov MS | Stockwell BR | Wigby K | Xia X
