7lay

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Current revision (15:42, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7lay' size='340' side='right'caption='[[7lay]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
<StructureSection load='7lay' size='340' side='right'caption='[[7lay]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7lay]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LAY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7lay]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LAY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5W2:4-[[4-[[3-(~{TERT}-BUTYLSULFONYLAMINO)-4-CHLORANYL-PHENYL]AMINO]-5-METHYL-PYRIMIDIN-2-YL]AMINO]-2-FLUORANYL-~{N}-(1-METHYLPIPERIDIN-4-YL)BENZAMIDE'>5W2</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD3, KIAA0043, RING3L ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5W2:4-[[4-[[3-(~{TERT}-BUTYLSULFONYLAMINO)-4-CHLORANYL-PHENYL]AMINO]-5-METHYL-PYRIMIDIN-2-YL]AMINO]-2-FLUORANYL-~{N}-(1-METHYLPIPERIDIN-4-YL)BENZAMIDE'>5W2</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lay OCA], [https://pdbe.org/7lay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lay RCSB], [https://www.ebi.ac.uk/pdbsum/7lay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lay ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lay OCA], [https://pdbe.org/7lay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lay RCSB], [https://www.ebi.ac.uk/pdbsum/7lay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lay ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN]] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.
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[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN]] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref>
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[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7lay" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7lay" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bikowitz, M J]]
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[[Category: Bikowitz MJ]]
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[[Category: Karim, M R]]
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[[Category: Karim MR]]
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[[Category: Schonbrunn, E]]
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[[Category: Schonbrunn E]]
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[[Category: Bet]]
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[[Category: Dual brd-kinase inhibitor]]
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[[Category: Erk5]]
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[[Category: Gene regulation]]
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[[Category: Gene regulation-inhibitor complex]]
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Current revision

Crystal structure of the first bromodomain (BD1) of human BRD3 bound to SG3-179

PDB ID 7lay

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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