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7lqd

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Current revision (15:56, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7lqd' size='340' side='right'caption='[[7lqd]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='7lqd' size='340' side='right'caption='[[7lqd]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7lqd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LQD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7lqd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LQD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TOE:2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL'>TOE</scene>, <scene name='pdbligand=YB4:~{N}-(2,6-diethylphenyl)-2-[[4-(4-methylpiperazin-1-yl)-2-(propanoylamino)phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide'>YB4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TOE:2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL'>TOE</scene>, <scene name='pdbligand=YB4:~{N}-(2,6-diethylphenyl)-2-[[4-(4-methylpiperazin-1-yl)-2-(propanoylamino)phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide'>YB4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lqd OCA], [https://pdbe.org/7lqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lqd RCSB], [https://www.ebi.ac.uk/pdbsum/7lqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lqd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lqd OCA], [https://pdbe.org/7lqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lqd RCSB], [https://www.ebi.ac.uk/pdbsum/7lqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lqd ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dual-specificity kinase]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arruda, P]]
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[[Category: Arruda P]]
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[[Category: Counago, R M]]
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[[Category: Counago RM]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Massirer, K B]]
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[[Category: Massirer KB]]
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[[Category: Reis, C V.dos]]
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[[Category: Santiago AS]]
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[[Category: Structural genomic]]
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[[Category: Serafim RAM]]
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[[Category: Santiago, A S]]
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[[Category: Dos Reis CV]]
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[[Category: Serafim, R A.M]]
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[[Category: Inhibitor]]
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[[Category: Protein kinase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Structure of Human MPS1 (TTK) covalently bound to RMS-07 inhibitor

PDB ID 7lqd

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