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1nl4

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[[Image:1nl4.jpg|left|200px]]
[[Image:1nl4.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1nl4 |SIZE=350|CAPTION= <scene name='initialview01'>1nl4</scene>, resolution 2.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1nl4", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FTL:4-[(3-CYANO-BENZYL)-(3-METHYL-3H-IMIDAZOL-4-YLMETHYL)-AMINO]-2-NAPHTHALEN-1-YL-BENZONITRILE'>FTL</scene>, <scene name='pdbligand=HFP:ALPHA-HYDROXYFARNESYLPHOSPHONIC+ACID'>HFP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= FNTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), FNTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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-->
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|DOMAIN=
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{{STRUCTURE_1nl4| PDB=1nl4 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nl4 OCA], [http://www.ebi.ac.uk/pdbsum/1nl4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nl4 RCSB]</span>
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}}
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'''Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor'''
'''Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor'''
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[[Category: Muchmore, S W.]]
[[Category: Muchmore, S W.]]
[[Category: Sham, H L.]]
[[Category: Sham, H L.]]
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[[Category: prenyltransferase]]
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[[Category: Prenyltransferase]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:39:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:31:54 2008''
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Revision as of 23:39, 2 May 2008

Image:1nl4.jpg

Template:STRUCTURE 1nl4

Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor


Overview

A series of imidazole-containing biphenyls was prepared and evaluated in vitro for inhibition of FTase and cellular Ras processing. Several of these analogues, such as 21, are potent inhibitors of FTase (<1nM), FTase/GGTase selective (>300-fold) and cellularly active (<or=80nM). An X-ray crystal structure of inhibitor 21 bound to rat farnesyltransferase is also presented.

About this Structure

1NL4 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase., Curtin ML, Florjancic AS, Cohen J, Gu WZ, Frost DJ, Muchmore SW, Sham HL, Bioorg Med Chem Lett. 2003 Apr 7;13(7):1367-71. PMID:12657284 Page seeded by OCA on Sat May 3 02:39:47 2008

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