7m40
From Proteopedia
(Difference between revisions)
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==Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)== | ==Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)== | ||
| - | <StructureSection load='7m40' size='340' side='right'caption='[[7m40]]' scene=''> | + | <StructureSection load='7m40' size='340' side='right'caption='[[7m40]], [[Resolution|resolution]] 1.88Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M40 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7m40]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M40 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m40 OCA], [https://pdbe.org/7m40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m40 RCSB], [https://www.ebi.ac.uk/pdbsum/7m40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m40 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YQJ:N~3~-{4-[3-(dimethylamino)pyrrolidin-1-yl]-6,7-dimethoxyquinazolin-2-yl}-N~1~,N~1~-dimethylpropane-1,3-diamine'>YQJ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m40 OCA], [https://pdbe.org/7m40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m40 RCSB], [https://www.ebi.ac.uk/pdbsum/7m40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m40 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Abbey M]] | [[Category: Abbey M]] | ||
Current revision
Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)
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Categories: Homo sapiens | Large Structures | Abbey M | Al-awar R | Arrowsmith CH | Brown PJ | Dong A | Ensan D | Gibson E | Marcellus R | McLeod D | Mohammed M | Panagopoulos D | Perveen S | Schapira M | Tempel W | Trush V | Vedadi M | Zepeda-Velazquez C
