We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
7mto
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal Structure of SET/I2PP2A/TAF-1Beta core== | ==Crystal Structure of SET/I2PP2A/TAF-1Beta core== | ||
| - | <StructureSection load='7mto' size='340' side='right'caption='[[7mto]]' scene=''> | + | <StructureSection load='7mto' size='340' side='right'caption='[[7mto]], [[Resolution|resolution]] 1.79Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MTO FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7mto]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MTO FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mto OCA], [https://pdbe.org/7mto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mto RCSB], [https://www.ebi.ac.uk/pdbsum/7mto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mto ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.791Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mto OCA], [https://pdbe.org/7mto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mto RCSB], [https://www.ebi.ac.uk/pdbsum/7mto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mto ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SET_HUMAN SET_HUMAN] Note=A chromosomal aberration involving SET is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with NUP214/CAN. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SET_HUMAN SET_HUMAN] Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: DePalma RM]] | [[Category: DePalma RM]] | ||
[[Category: Ogretmen B]] | [[Category: Ogretmen B]] | ||
[[Category: Roth BM]] | [[Category: Roth BM]] | ||
Current revision
Crystal Structure of SET/I2PP2A/TAF-1Beta core
| |||||||||||
