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7n3l

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Current revision (16:23, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7n3l' size='340' side='right'caption='[[7n3l]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
<StructureSection load='7n3l' size='340' side='right'caption='[[7n3l]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7n3l]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N3L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7n3l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N3L FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=04Y:N-cyclopropyl-1-(4-phenylpyridin-3-yl)piperidine-4-carboxamide'>04Y</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.631&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cholesterol_24-hydroxylase Cholesterol 24-hydroxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.25 1.14.14.25] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=04Y:N-cyclopropyl-1-(4-phenylpyridin-3-yl)piperidine-4-carboxamide'>04Y</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n3l OCA], [https://pdbe.org/7n3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n3l RCSB], [https://www.ebi.ac.uk/pdbsum/7n3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n3l ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n3l OCA], [https://pdbe.org/7n3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n3l RCSB], [https://www.ebi.ac.uk/pdbsum/7n3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n3l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CP46A_HUMAN CP46A_HUMAN]] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.
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[https://www.uniprot.org/uniprot/CP46A_HUMAN CP46A_HUMAN] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cholesterol 24-hydroxylase]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lane, W]]
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[[Category: Lane W]]
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[[Category: Yano, J]]
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[[Category: Yano J]]
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[[Category: Ch24h]]
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[[Category: Cyp46a1]]
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[[Category: Drug discovery]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Sbdd]]
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Current revision

Co-complex CYP46A1 with 0420 (compound 6)

PDB ID 7n3l

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