7n7x

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<StructureSection load='7n7x' size='340' side='right'caption='[[7n7x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='7n7x' size='340' side='right'caption='[[7n7x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7n7x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N7X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7n7x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N7X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0RI:Orladeyo'>0RI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.097&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2any|2any]], [[2anw|2anw]], [[5tjx|5tjx]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0RI:Orladeyo'>0RI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n7x OCA], [https://pdbe.org/7n7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n7x RCSB], [https://www.ebi.ac.uk/pdbsum/7n7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n7x ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n7x OCA], [https://pdbe.org/7n7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n7x RCSB], [https://www.ebi.ac.uk/pdbsum/7n7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n7x ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[https://omim.org/entry/612423 612423]]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.
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[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[https://omim.org/entry/612423 612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
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[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7n7x" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7n7x" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Kallikrein 3D structures|Kallikrein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kotian, P]]
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[[Category: Kotian P]]
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[[Category: Krishnan, R]]
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[[Category: Krishnan R]]
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[[Category: Polach, K J]]
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[[Category: Polach KJ]]
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[[Category: Yarlagadda, B S]]
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[[Category: Yarlagadda BS]]
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[[Category: Zhang, W]]
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[[Category: Zhang W]]
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[[Category: Acute hereditary angioedema]]
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[[Category: Blood]]
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[[Category: Bradykinin]]
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[[Category: Edema]]
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[[Category: Fletcher factor]]
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[[Category: Hae]]
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[[Category: Haw]]
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[[Category: Hereditary angioedema]]
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[[Category: Hmwk]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Kallikrein]]
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[[Category: Kininogenin]]
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[[Category: Orladeyo]]
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[[Category: Plasma]]
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[[Category: Plasma kallikrein-mediated edema]]
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[[Category: Serine protease]]
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Revision as of 16:25, 18 October 2023

Crystal structure of BCX7353(ORLADEYO) in complex with human plasma kallikrein serine protease domain at 2.1 angstrom resolution

PDB ID 7n7x

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