7n9v

==CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions==

<StructureSection load='7n9v' size='340' side='right'caption='[[7n9v]], [[Resolution|resolution]] 3.45&Aring;' scene=''>

<table><tr><td colspan='2'>[[7n9v]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N9V FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.45&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n9v OCA], [https://pdbe.org/7n9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n9v RCSB], [https://www.ebi.ac.uk/pdbsum/7n9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n9v ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).

[[Category: Human immunodeficiency virus 1]]

[[Category: Lama glama]]

[[Category: Tripler TN]]