7rea
From Proteopedia
(Difference between revisions)
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==Apo Hemophilin from A. baumannii== | ==Apo Hemophilin from A. baumannii== | ||
| - | <StructureSection load='7rea' size='340' side='right'caption='[[7rea]]' scene=''> | + | <StructureSection load='7rea' size='340' side='right'caption='[[7rea]], [[Resolution|resolution]] 1.49Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7REA FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7rea]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_NIPH_201 Acinetobacter baumannii NIPH 201]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7REA FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rea OCA], [https://pdbe.org/7rea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rea RCSB], [https://www.ebi.ac.uk/pdbsum/7rea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rea ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rea OCA], [https://pdbe.org/7rea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rea RCSB], [https://www.ebi.ac.uk/pdbsum/7rea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rea ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A086I049_ACIBA A0A086I049_ACIBA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Nutrient acquisition systems are often crucial for pathogen growth and survival during infection, and represent attractive therapeutic targets. Here, we study the protein machinery required for heme uptake in the opportunistic pathogen Acinetobacter baumannii. We show that the hemO locus, which includes a gene encoding the heme-degrading enzyme, is required for high-affinity heme acquisition from hemoglobin and serum albumin. The hemO locus includes a gene coding for a heme scavenger (HphA), which is secreted by a Slam protein. Furthermore, heme uptake is dependent on a TonB-dependent receptor (HphR), which is important for survival and/or dissemination into the vasculature in a mouse model of pulmonary infection. Our results indicate that A. baumannii uses a two-component receptor system for the acquisition of heme from host heme reservoirs. | ||
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| + | A Slam-dependent hemophore contributes to heme acquisition in the bacterial pathogen Acinetobacter baumannii.,Bateman TJ, Shah M, Ho TP, Shin HE, Pan C, Harris G, Fegan JE, Islam EA, Ahn SK, Hooda Y, Gray-Owen SD, Chen W, Moraes TF Nat Commun. 2021 Nov 1;12(1):6270. doi: 10.1038/s41467-021-26545-9. PMID:34725337<ref>PMID:34725337</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7rea" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Acinetobacter baumannii NIPH 201]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bateman TJ]] | [[Category: Bateman TJ]] | ||
[[Category: Moraes TF]] | [[Category: Moraes TF]] | ||
[[Category: Shah M]] | [[Category: Shah M]] | ||
Current revision
Apo Hemophilin from A. baumannii
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