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7rot

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Current revision (16:34, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7rot' size='340' side='right'caption='[[7rot]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='7rot' size='340' side='right'caption='[[7rot]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7rot]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ROT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ROT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7rot]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ROT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ROT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=66I:{(2R,3S,4R,5R)-5-[4-amino-3-(difluoromethoxy)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxyoxolan-2-yl}methyl+[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]sulfamate+(non-preferred+name)'>66I</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=66I:{(2R,3S,4R,5R)-5-[4-amino-3-(difluoromethoxy)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxyoxolan-2-yl}methyl+[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]sulfamate+(non-preferred+name)'>66I</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rot OCA], [https://pdbe.org/7rot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rot RCSB], [https://www.ebi.ac.uk/pdbsum/7rot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rot ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rot OCA], [https://pdbe.org/7rot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rot RCSB], [https://www.ebi.ac.uk/pdbsum/7rot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rot ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8IAR7_PLAF7 Q8IAR7_PLAF7]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7rot" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7rot" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Tyrosine--tRNA ligase]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Griffin, M D.W]]
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[[Category: Griffin MDW]]
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[[Category: Metcalfe, R D]]
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[[Category: Metcalfe RD]]
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[[Category: Morton, C J]]
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[[Category: Morton CJ]]
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[[Category: Tilley, L]]
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[[Category: Tilley L]]
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[[Category: Xie, S C]]
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[[Category: Xie SC]]
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[[Category: Enzyme]]
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[[Category: Inhibitor]]
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[[Category: Ligase]]
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[[Category: Malaria]]
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[[Category: Tyrosine-amp]]
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[[Category: Tyrosyl-trna synthetase]]
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Current revision

Plasmodium falciparum tyrosyl-tRNA synthetase, S234C mutant, in complex with ML901-Tyr

PDB ID 7rot

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OCA

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