7s2z
From Proteopedia
(Difference between revisions)
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==Crystal structure of the E100A mutant TIR domain from the grapevine disease resistance protein RUN1 bound to NAD== | ==Crystal structure of the E100A mutant TIR domain from the grapevine disease resistance protein RUN1 bound to NAD== | ||
| - | <StructureSection load='7s2z' size='340' side='right'caption='[[7s2z]]' scene=''> | + | <StructureSection load='7s2z' size='340' side='right'caption='[[7s2z]], [[Resolution|resolution]] 2.35Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S2Z FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7s2z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vitis_rotundifolia Vitis rotundifolia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S2Z FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s2z OCA], [https://pdbe.org/7s2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s2z RCSB], [https://www.ebi.ac.uk/pdbsum/7s2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s2z ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s2z OCA], [https://pdbe.org/7s2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s2z RCSB], [https://www.ebi.ac.uk/pdbsum/7s2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s2z ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RUN1_VITRO RUN1_VITRO] Disease resistance (R) protein that confers resistance to multiple powdery and downy mildew by promoting cell death (PubMed:24033846, PubMed:31439792). Acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death (PubMed:31439792). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:31439792).<ref>PMID:24033846</ref> <ref>PMID:31439792</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Vitis rotundifolia]] | ||
[[Category: Burdett H]] | [[Category: Burdett H]] | ||
[[Category: Kobe B]] | [[Category: Kobe B]] | ||
Current revision
Crystal structure of the E100A mutant TIR domain from the grapevine disease resistance protein RUN1 bound to NAD
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