7sty
From Proteopedia
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==Crystal structure of human CORO1C== | ==Crystal structure of human CORO1C== | ||
| - | <StructureSection load='7sty' size='340' side='right'caption='[[7sty]]' scene=''> | + | <StructureSection load='7sty' size='340' side='right'caption='[[7sty]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7STY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7STY FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7sty]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7STY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7STY FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sty OCA], [https://pdbe.org/7sty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sty RCSB], [https://www.ebi.ac.uk/pdbsum/7sty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sty ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sty OCA], [https://pdbe.org/7sty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sty RCSB], [https://www.ebi.ac.uk/pdbsum/7sty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sty ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/COR1C_HUMAN COR1C_HUMAN] Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity).[UniProtKB:Q9WUM4]<ref>PMID:25074804</ref> <ref>PMID:25925950</ref> <ref>PMID:30220460</ref> <ref>PMID:34106209</ref> Involved in myogenic differentiation.<ref>PMID:19651142</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith CH]] | [[Category: Arrowsmith CH]] | ||
Current revision
Crystal structure of human CORO1C
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Dong A | Edwards AM | Halabelian L | Hutchinson A | Loppnau P | Seitova A | Zeng H
