7ta9

<StructureSection load='7ta9' size='340' side='right'caption='[[7ta9]], [[Resolution|resolution]] 1.50&Aring;' scene=''>

<table><tr><td colspan='2'>[[7ta9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TA9 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ta9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ta9 OCA], [https://pdbe.org/7ta9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ta9 RCSB], [https://www.ebi.ac.uk/pdbsum/7ta9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ta9 ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/TYSY_ACIB5 TYSY_ACIB5] Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.[HAMAP-Rule:MF_00008]

==See Also==

*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]

[[Category: Acinetobacter baumannii]]