8dys
From Proteopedia
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==Crystal structure of human Eukaryotic translation initiation factor 2A (eIF2A)== | ==Crystal structure of human Eukaryotic translation initiation factor 2A (eIF2A)== | ||
| - | <StructureSection load='8dys' size='340' side='right'caption='[[8dys]]' scene=''> | + | <StructureSection load='8dys' size='340' side='right'caption='[[8dys]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DYS FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[8dys]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DYS FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dys OCA], [https://pdbe.org/8dys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dys RCSB], [https://www.ebi.ac.uk/pdbsum/8dys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dys ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dys OCA], [https://pdbe.org/8dys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dys RCSB], [https://www.ebi.ac.uk/pdbsum/8dys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dys ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/EIF2A_HUMAN EIF2A_HUMAN] Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.<ref>PMID:12133843</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith CH]] | [[Category: Arrowsmith CH]] | ||
Current revision
Crystal structure of human Eukaryotic translation initiation factor 2A (eIF2A)
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Dong A | Edwards AM | Halabelian L | Hutchinson A | Li Y | Righetto GL | Seitova A | Zeng H
