1nnk

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[[Image:1nnk.gif|left|200px]]
[[Image:1nnk.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1nnk |SIZE=350|CAPTION= <scene name='initialview01'>1nnk</scene>, resolution 1.85&Aring;
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The line below this paragraph, containing "STRUCTURE_1nnk", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CE2:3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE'>CE2</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_1nnk| PDB=1nnk | SCENE= }}
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|RELATEDENTRY=[[1ftj|1FTJ]], [[1ftk|1FTK]], [[1fto|1FTO]], [[1fw0|1FW0]], [[1ftl|1FTL]], [[1gr2|1GR2]], [[1lb8|1LB8]], [[1lb9|1LB9]], [[1lbc|1LBC]], [[1m5e|1M5E]], [[1m5c|1M5C]], [[1m5b|1M5B]], [[1m5f|1M5F]], [[1mm7|1MM7]], [[1mm6|1MM6]], [[1lbb|1LBB]], [[1my4|1MY4]], [[1my3|1MY3]], [[1m5d|1M5D]], [[1ftm|1FTM]], [[1nnp|1NNP]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nnk OCA], [http://www.ebi.ac.uk/pdbsum/1nnk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nnk RCSB]</span>
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}}
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'''X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.85 A resolution. Crystallization with zinc ions.'''
'''X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.85 A resolution. Crystallization with zinc ions.'''
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[[Category: Lunn, M L.]]
[[Category: Lunn, M L.]]
[[Category: Stensbol, T B.]]
[[Category: Stensbol, T B.]]
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[[Category: agonist complex]]
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[[Category: Agonist complex]]
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[[Category: ionotropic glutamate receptor glur2]]
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[[Category: Ionotropic glutamate receptor glur2]]
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[[Category: ligand-binding core]]
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[[Category: Ligand-binding core]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:45:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:32:51 2008''
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Revision as of 23:45, 2 May 2008

Image:1nnk.gif

Template:STRUCTURE 1nnk

X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.85 A resolution. Crystallization with zinc ions.


Overview

Two X-ray structures of the GluR2 ligand-binding core in complex with (S)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid ((S)-ATPA) have been determined with and without Zn(2+) ions. (S)-ATPA induces a domain closure of ca. 21 degrees compared to the apo form. The tert-butyl moiety of (S)-ATPA is buried in a partially hydrophobic pocket and forces the ligand into the glutamate-like binding mode. The structures provide new insight into the molecular basis of agonist selectivity between AMPA and kainate receptors.

About this Structure

1NNK is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity., Lunn ML, Hogner A, Stensbol TB, Gouaux E, Egebjerg J, Kastrup JS, J Med Chem. 2003 Feb 27;46(5):872-5. PMID:12593667 Page seeded by OCA on Sat May 3 02:45:04 2008

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OCA

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