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5lqn
From Proteopedia
(Difference between revisions)
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<StructureSection load='5lqn' size='340' side='right'caption='[[5lqn]], [[Resolution|resolution]] 1.72Å' scene=''> | <StructureSection load='5lqn' size='340' side='right'caption='[[5lqn]], [[Resolution|resolution]] 1.72Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5lqn]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5lqn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LQN FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=72O:2-[(3-CHLORANYLPHENOXY)METHYL]-4-METHYL-5-(1~{H}-PYRAZOL-5-YL)-1,3-THIAZOLE'>72O</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lqn OCA], [https://pdbe.org/5lqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lqn RCSB], [https://www.ebi.ac.uk/pdbsum/5lqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lqn ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Buffalo rat]] | ||
| - | [[Category: Catechol O-methyltransferase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| - | [[Category: | + | [[Category: Ehler A]] |
| - | [[Category: | + | [[Category: Lerner C]] |
| - | [[Category: | + | [[Category: Rudolph MG]] |
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of COMT in complex with 2-[(3-chlorophenoxy)methyl]-4-methyl-5-(1H-pyrazol-5-yl)-1,3-thiazole
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