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| - | | + | #REDIRECT [[8p7i]] This PDB entry is obsolete and replaced by 8p7i |
| - | ==Phosphotriesterase PTE_A53_1==
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| - | <StructureSection load='6fei' size='340' side='right'caption='[[6fei]], [[Resolution|resolution]] 1.70Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[6fei]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FEI FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D6K:(4~{S},6~{R})-2,2,6-trimethyl-1,3-dioxan-4-ol'>D6K</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6fee|6fee]], [[6fef|6fef]]</div></td></tr>
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| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">opd ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aryldialkylphosphatase Aryldialkylphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.1 3.1.8.1] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fei OCA], [https://pdbe.org/6fei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fei RCSB], [https://www.ebi.ac.uk/pdbsum/6fei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fei ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[https://www.uniprot.org/uniprot/OPD_BREDI OPD_BREDI]] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate.
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Bacillus coli migula 1895]]
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| - | [[Category: Aryldialkylphosphatase]]
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| - | [[Category: Large Structures]]
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| - | [[Category: Aggarwal, N]]
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| - | [[Category: Albeck, S]]
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| - | [[Category: Ashani, Y]]
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| - | [[Category: Dym, O]]
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| - | [[Category: Goldsmith, M]]
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| - | [[Category: Greisen, P]]
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| - | [[Category: Leader, H]]
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| - | [[Category: Rogotner, S Hamer]]
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| - | [[Category: Silman, I]]
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| - | [[Category: Sussman, L J]]
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| - | [[Category: Tawfik, D]]
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| - | [[Category: Unger, T]]
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| - | [[Category: Hydrolase]]
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| - | [[Category: Metalloenzyme]]
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| - | [[Category: Tim barrel]]
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