1nos

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[[Image:1nos.jpg|left|200px]]
[[Image:1nos.jpg|left|200px]]
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{{Structure
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|PDB= 1nos |SIZE=350|CAPTION= <scene name='initialview01'>1nos</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1nos", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase Nitric-oxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span>
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1nos| PDB=1nos | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nos OCA], [http://www.ebi.ac.uk/pdbsum/1nos PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nos RCSB]</span>
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}}
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'''MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114), IMIDAZOLE COMPLEX'''
'''MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114), IMIDAZOLE COMPLEX'''
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[[Category: Stuehr, D J.]]
[[Category: Stuehr, D J.]]
[[Category: Tainer, J A.]]
[[Category: Tainer, J A.]]
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[[Category: heme]]
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[[Category: Heme]]
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[[Category: imidazole]]
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[[Category: Imidazole]]
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[[Category: l-arginine monooxygenase]]
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[[Category: L-arginine monooxygenase]]
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[[Category: nitric oxide]]
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[[Category: Nitric oxide]]
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[[Category: no]]
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[[Category: No]]
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[[Category: no]]
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[[Category: No]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:47:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:33:21 2008''
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Revision as of 23:47, 2 May 2008

Image:1nos.jpg

Template:STRUCTURE 1nos

MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114), IMIDAZOLE COMPLEX


Overview

The nitric oxide synthase oxygenase domain (NOSox) oxidizes arginine to synthesize the cellular signal and defensive cytotoxin nitric oxide (NO). Crystal structures determined for cytokine-inducible NOSox reveal an unusual fold and heme environment for stabilization of activated oxygen intermediates key for catalysis. A winged beta sheet engenders a curved alpha-beta domain resembling a baseball catcher's mitt with heme clasped in the palm. The location of exposed hydrophobic residues and the results of mutational analysis place the dimer interface adjacent to the heme-binding pocket. Juxtaposed hydrophobic O2- and polar L-arginine-binding sites occupied by imidazole and aminoguanidine, respectively, provide a template for designing dual-function inhibitors and imply substrate-assisted catalysis.

About this Structure

1NOS is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of nitric oxide synthase oxygenase domain and inhibitor complexes., Crane BR, Arvai AS, Gachhui R, Wu C, Ghosh DK, Getzoff ED, Stuehr DJ, Tainer JA, Science. 1997 Oct 17;278(5337):425-31. PMID:9334294 Page seeded by OCA on Sat May 3 02:47:35 2008

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