1nox

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[[Image:1nox.gif|left|200px]]
[[Image:1nox.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1nox |SIZE=350|CAPTION= <scene name='initialview01'>1nox</scene>, resolution 1.59&Aring;
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The line below this paragraph, containing "STRUCTURE_1nox", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=COF:Cofactor'>COF</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/NADH_dehydrogenase NADH dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.99.3 1.6.99.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1nox| PDB=1nox | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nox OCA], [http://www.ebi.ac.uk/pdbsum/1nox PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nox RCSB]</span>
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}}
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'''NADH OXIDASE FROM THERMUS THERMOPHILUS'''
'''NADH OXIDASE FROM THERMUS THERMOPHILUS'''
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[[Category: Schmid, R D.]]
[[Category: Schmid, R D.]]
[[Category: Sprinzl, M.]]
[[Category: Sprinzl, M.]]
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[[Category: flavoenzyme]]
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[[Category: Flavoenzyme]]
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[[Category: flavoprotein fmn]]
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[[Category: Flavoprotein fmn]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: thermophile]]
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[[Category: Thermophile]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:47:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:33:24 2008''
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Revision as of 23:47, 2 May 2008

Image:1nox.gif

Template:STRUCTURE 1nox

NADH OXIDASE FROM THERMUS THERMOPHILUS


Overview

The crystal structures of the flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) containing isoforms of NADH oxidase from Thermus thermophilus have been determined by isomorphous and molecular replacement and refined to 2.3 A and 1.6 A resolution with R-values of 18.5% and 18.6% respectively. The structure of the homodimeric enzyme consists of a central 4-stranded antiparallel beta-sheet covered by helices, a more flexible domain formed by two helices, and a C-terminal excursion connecting the subunits. The active sites are located in a deep cleft between the subunits. The binding site of the flavin cofactor lacks the common nucleotide binding fold and is different from the FMN binding site found in flavodoxins.

About this Structure

1NOX is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of NADH oxidase from Thermus thermophilus., Hecht HJ, Erdmann H, Park HJ, Sprinzl M, Schmid RD, Nat Struct Biol. 1995 Dec;2(12):1109-14. PMID:8846223 Page seeded by OCA on Sat May 3 02:47:57 2008

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