1skg
From Proteopedia
(Difference between revisions)
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<StructureSection load='1skg' size='340' side='right'caption='[[1skg]], [[Resolution|resolution]] 1.21Å' scene=''> | <StructureSection load='1skg' size='340' side='right'caption='[[1skg]], [[Resolution|resolution]] 1.21Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1skg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1skg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_pulchella Daboia russelii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SKG FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.21Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1skg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skg OCA], [https://pdbe.org/1skg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1skg RCSB], [https://www.ebi.ac.uk/pdbsum/1skg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1skg ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1skg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skg OCA], [https://pdbe.org/1skg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1skg RCSB], [https://www.ebi.ac.uk/pdbsum/1skg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1skg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]] | *[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Daboia pulchella]] | + | [[Category: Daboia russelii pulchella]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Betzel | + | [[Category: Betzel C]] |
| - | [[Category: Dey | + | [[Category: Dey S]] |
| - | [[Category: Ethayathulla | + | [[Category: Ethayathulla AS]] |
| - | [[Category: Makker | + | [[Category: Makker J]] |
| - | [[Category: Perbandt | + | [[Category: Perbandt M]] |
| - | [[Category: Sharma | + | [[Category: Sharma S]] |
| - | [[Category: Singh | + | [[Category: Singh N]] |
| - | [[Category: Singh | + | [[Category: Singh TP]] |
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Revision as of 07:26, 25 October 2023
Structure-based rational drug design: Crystal structure of the complex formed between Phospholipase A2 and a pentapeptide Val-Ala-Phe-Arg-Ser
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