1tdk
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1tdk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TDK FirstGlance]. <br> | <table><tr><td colspan='2'>[[1tdk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TDK FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=LVG:L-VINYLGLYCINE'>LVG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tdk OCA], [https://pdbe.org/1tdk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tdk RCSB], [https://www.ebi.ac.uk/pdbsum/1tdk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tdk ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tdk OCA], [https://pdbe.org/1tdk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tdk RCSB], [https://www.ebi.ac.uk/pdbsum/1tdk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tdk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/OXLA_GLOHA OXLA_GLOHA] Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity). This protein induces apoptosis of cultured HeLa cells.<ref>PMID:15103157</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 29: | Line 28: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Gloydius halys]] | [[Category: Gloydius halys]] | ||
| - | [[Category: L-amino-acid oxidase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Niu | + | [[Category: Niu L]] |
| - | [[Category: Teng | + | [[Category: Teng M]] |
| - | [[Category: Zhang | + | [[Category: Zhang H]] |
| - | + | ||
| - | + | ||
Revision as of 07:27, 25 October 2023
L-amino acid oxidase from Agkistrodon halys in complex with suicide substrate L-vinylglycine
| |||||||||||
