1tdn
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1tdn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TDN FirstGlance]. <br> | <table><tr><td colspan='2'>[[1tdn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TDN FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tdn OCA], [https://pdbe.org/1tdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tdn RCSB], [https://www.ebi.ac.uk/pdbsum/1tdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tdn ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tdn OCA], [https://pdbe.org/1tdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tdn RCSB], [https://www.ebi.ac.uk/pdbsum/1tdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tdn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/OXLA_GLOHA OXLA_GLOHA] Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity). This protein induces apoptosis of cultured HeLa cells.<ref>PMID:15103157</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Gloydius halys]] | [[Category: Gloydius halys]] | ||
| - | [[Category: L-amino-acid oxidase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Niu | + | [[Category: Niu L]] |
| - | [[Category: Teng | + | [[Category: Teng M]] |
| - | [[Category: Zhang | + | [[Category: Zhang H]] |
| - | + | ||
Revision as of 07:27, 25 October 2023
L-amino acid oxidase from Agkistrodon halys in complex with L-leucine
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