1npo

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[[Image:1npo.gif|left|200px]]
[[Image:1npo.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1npo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npo OCA], [http://www.ebi.ac.uk/pdbsum/1npo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1npo RCSB]</span>
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'''BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN'''
'''BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN'''
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[[Category: Rose, J P.]]
[[Category: Rose, J P.]]
[[Category: Wang, B C.]]
[[Category: Wang, B C.]]
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[[Category: complex (hormone transport/hormone)]]
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[[Category: Hypothalamus]]
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[[Category: hypothalamus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:49:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:33:43 2008''
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Revision as of 23:49, 2 May 2008

Image:1npo.gif

Template:STRUCTURE 1npo

BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN


Overview

The first crystal structure of the pituitary hormone oxytocin complexed with its carrier protein neurophysin has been determined and refined to 3.0 A resolution. The hormone-binding site is located at the end of a 3(10)-helix and involves residues from both domains of each monomer. Hormone residues Tyr 2, which is buried deep in the binding pocket, and Cys 1 have been confirmed as the key residues involved in neurophysin-hormone recognition. We have compared the bound oxytocin observed in the neurophysin-oxytocin complex, the X-ray structures of unbound oxytocin analogues and the NMR-derived structure for bound oxytocin. We find that while our structure is in agreement with the previous crystallographic findings, it differs from the NMR result with regard to how Tyr 2 of the hormone is recognized by neurophysin.

About this Structure

1NPO is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the neurophysin-oxytocin complex., Rose JP, Wu CK, Hsiao CD, Breslow E, Wang BC, Nat Struct Biol. 1996 Feb;3(2):163-9. PMID:8564543 Page seeded by OCA on Sat May 3 02:49:40 2008

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