1ufr

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<StructureSection load='1ufr' size='340' side='right'caption='[[1ufr]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='1ufr' size='340' side='right'caption='[[1ufr]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ufr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UFR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ufr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UFR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ufr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ufr OCA], [https://pdbe.org/1ufr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ufr RCSB], [https://www.ebi.ac.uk/pdbsum/1ufr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ufr ProSAT], [https://www.topsan.org/Proteins/RSGI/1ufr TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ufr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ufr OCA], [https://pdbe.org/1ufr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ufr RCSB], [https://www.ebi.ac.uk/pdbsum/1ufr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ufr ProSAT], [https://www.topsan.org/Proteins/RSGI/1ufr TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PYRR_THET8 PYRR_THET8]] Probably regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. In contrast to pyr attenuation in Bacillus, PyrR from Thermus could act as a translational repressor: the binding of PyrR at its proposed recognition site in the transcript would prevent initiation of translation of the leader peptide, resulting in terminator formation and reduced expression of downstream genes (By similarity). Also displays uracil phosphoribosyltransferase activity (By similarity).
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[https://www.uniprot.org/uniprot/PYRR_THET8 PYRR_THET8] Probably regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. In contrast to pyr attenuation in Bacillus, PyrR from Thermus could act as a translational repressor: the binding of PyrR at its proposed recognition site in the transcript would prevent initiation of translation of the leader peptide, resulting in terminator formation and reduced expression of downstream genes (By similarity). Also displays uracil phosphoribosyltransferase activity (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kuramitsu, S]]
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[[Category: Thermus thermophilus]]
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[[Category: Matsuura, T]]
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[[Category: Kuramitsu S]]
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[[Category: Structural genomic]]
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[[Category: Matsuura T]]
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[[Category: Sakai, H]]
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[[Category: Sakai H]]
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[[Category: Shirouzu, M]]
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[[Category: Shirouzu M]]
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[[Category: Terada, T]]
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[[Category: Terada T]]
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[[Category: Yokoyama, S]]
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[[Category: Yokoyama S]]
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[[Category: Pyrimidine nucleotide biosynthesis]]
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[[Category: Rna binding protein]]
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[[Category: Rna-binding protein]]
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[[Category: Rsgi]]
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[[Category: Transcriptional attenuation]]
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[[Category: Uracil phosphoribosyltransferase]]
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Revision as of 07:35, 25 October 2023

Crystal Structure of TT1027 from Thermus thermophilus HB8

PDB ID 1ufr

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