1ujz

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Current revision (07:40, 25 October 2023) (edit) (undo)
 
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<StructureSection load='1ujz' size='340' side='right'caption='[[1ujz]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='1ujz' size='340' side='right'caption='[[1ujz]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ujz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UJZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ujz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UJZ FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7cei|7cei]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CEIE7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ujz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujz OCA], [https://pdbe.org/1ujz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ujz RCSB], [https://www.ebi.ac.uk/pdbsum/1ujz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ujz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ujz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujz OCA], [https://pdbe.org/1ujz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ujz RCSB], [https://www.ebi.ac.uk/pdbsum/1ujz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ujz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/IMM7_ECOLX IMM7_ECOLX]] This protein is able to protect a cell, which harbors the plasmid ColE7 encoding colicin E7, against colicin E7, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity. Dimeric ImmE7 may possess a RNase activity that cleaves its own mRNA at a specific site and thus autoregulates translational expression of the downstream ceiE7 gene as well as degradation of the upstream ceaE7 mRNA. [[https://www.uniprot.org/uniprot/CEA7_ECOLX CEA7_ECOLX]] This plasmid-coded bactericidal protein is an endonuclease active on both single- and double-stranded DNA but with undefined specificity. Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
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[https://www.uniprot.org/uniprot/IMM7_ECOLX IMM7_ECOLX] This protein is able to protect a cell, which harbors the plasmid ColE7 encoding colicin E7, against colicin E7, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity. Dimeric ImmE7 may possess a RNase activity that cleaves its own mRNA at a specific site and thus autoregulates translational expression of the downstream ceiE7 gene as well as degradation of the upstream ceaE7 mRNA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Baker, D]]
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[[Category: Baker D]]
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[[Category: Bullock, A N]]
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[[Category: Bullock AN]]
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[[Category: Joachimiak, L A]]
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[[Category: Joachimiak LA]]
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[[Category: Kortemme, T]]
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[[Category: Kortemme T]]
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[[Category: Schuler, A D]]
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[[Category: Schuler AD]]
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[[Category: Stoddard, B L]]
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[[Category: Stoddard BL]]
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[[Category: Computational design]]
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[[Category: Immune system]]
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[[Category: Molecular recognition]]
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[[Category: Protein complex]]
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[[Category: Redesigned protein-protein interface]]
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[[Category: Specificity]]
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Current revision

Crystal structure of the E7_C/Im7_C complex; a computationally designed interface between the colicin E7 DNase and the Im7 Immunity protein

PDB ID 1ujz

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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