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1npu

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[[Image:1npu.gif|left|200px]]
[[Image:1npu.gif|left|200px]]
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{{Structure
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|PDB= 1npu |SIZE=350|CAPTION= <scene name='initialview01'>1npu</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1npu", creates the "Structure Box" on the page.
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|SITE=
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|GENE= PDCD1 OR PD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00409 IG]</span>
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{{STRUCTURE_1npu| PDB=1npu | SCENE= }}
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|RELATEDENTRY=[[1b88|1B88]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1npu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npu OCA], [http://www.ebi.ac.uk/pdbsum/1npu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1npu RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1'''
'''CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1'''
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[[Category: Zhang, X.]]
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[[Category: Zhang, Z Y.]]
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[[Category: ig v-type domain]]
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[[Category: Ig v-type domain]]
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[[Category: new york structural genomix research consortium]]
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[[Category: New york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: Nysgxrc]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:50:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:33:48 2008''
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Revision as of 23:50, 2 May 2008

Image:1npu.gif

Template:STRUCTURE 1npu

CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1


Overview

PD-1, a member of the CD28/CTLA-4/ICOS costimulatory receptor family, delivers negative signals that have profound effects on T and B cell immunity. The 2.0 A crystal structure of the extracellular domain of murine PD-1 reveals an Ig V-type topology with overall similarity to the CTLA-4 monomer; however, there are notable differences in regions relevant to function. Our structural and biophysical data show that PD-1 is monomeric both in solution as well as on cell surface, in contrast to CTLA-4 and other family members that are all disulfide-linked homodimers. Furthermore, our structure-based mutagenesis studies identify the ligand binding surface of PD-1, which displays significant differences compared to those present in the other members of the family.

About this Structure

1NPU is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural and functional analysis of the costimulatory receptor programmed death-1., Zhang X, Schwartz JC, Guo X, Bhatia S, Cao E, Lorenz M, Cammer M, Chen L, Zhang ZY, Edidin MA, Nathenson SG, Almo SC, Immunity. 2004 Mar;20(3):337-47. PMID:15030777 Page seeded by OCA on Sat May 3 02:50:06 2008

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