1npx

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[[Image:1npx.jpg|left|200px]]
[[Image:1npx.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1npx |SIZE=350|CAPTION= <scene name='initialview01'>1npx</scene>, resolution 2.16&Aring;
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The line below this paragraph, containing "STRUCTURE_1npx", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CYO:OXYGENS+BOUND+TO+CYS+SG'>CYO</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/NADH_peroxidase NADH peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.1 1.11.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1npx| PDB=1npx | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1npx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npx OCA], [http://www.ebi.ac.uk/pdbsum/1npx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1npx RCSB]</span>
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}}
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'''STRUCTURE OF NADH PEROXIDASE FROM STREPTOCOCCUS FAECALIS 10C1 REFINED AT 2.16 ANGSTROMS RESOLUTION'''
'''STRUCTURE OF NADH PEROXIDASE FROM STREPTOCOCCUS FAECALIS 10C1 REFINED AT 2.16 ANGSTROMS RESOLUTION'''
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[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
[[Category: Stehle, T.]]
[[Category: Stehle, T.]]
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[[Category: oxidoreductase(h2o2(a))]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:50:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:33:52 2008''
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Revision as of 23:50, 2 May 2008

Image:1npx.jpg

Template:STRUCTURE 1npx

STRUCTURE OF NADH PEROXIDASE FROM STREPTOCOCCUS FAECALIS 10C1 REFINED AT 2.16 ANGSTROMS RESOLUTION


Overview

The crystal structure of NADH peroxidase (EC 1.11.1.1) from Streptococcus faecalis 10C1 (Enterococcus faecalis) has been refined to a resolution of 2.16 A using the simulated annealing method. The final crystallographic R-factor is 17.7% for all data in the resolution range 7 to 2.16 A. The standard deviations are 0.015 A in bond lengths and 3.0 degrees in bond angles for the final model, which includes all 447 amino acid residues, one FAD and 369 water molecules. The enzyme is a symmetrical tetramer with point group D2; the symmetry is crystallographic. The redox center of the enzyme consists of FAD and a cysteine (Cys42), which forms a sulfenic acid (Cys-SOH) in its oxidized state. A histidine (His10) close to Cys42 is likely to act as an active-site base. In the analyzed crystal, the enzyme was in a non-native oxidation state with Cys42 oxidized to a sulfonic acid Cys-SO3H. The chain fold of NADH peroxidase is similar to those of disulfide oxidoreductases. A comparison with glutathione reductase, a representative of this enzyme family, is given.

About this Structure

1NPX is a Single protein structure of sequence from Enterococcus faecalis. Full crystallographic information is available from OCA.

Reference

Structure of NADH peroxidase from Streptococcus faecalis 10C1 refined at 2.16 A resolution., Stehle T, Ahmed SA, Claiborne A, Schulz GE, J Mol Biol. 1991 Oct 20;221(4):1325-44. PMID:1942054 Page seeded by OCA on Sat May 3 02:50:18 2008

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