1xxu
From Proteopedia
(Difference between revisions)
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<StructureSection load='1xxu' size='340' side='right'caption='[[1xxu]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='1xxu' size='340' side='right'caption='[[1xxu]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[1xxu]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1xxu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XXU FirstGlance]. <br> |
- | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxu OCA], [https://pdbe.org/1xxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xxu RCSB], [https://www.ebi.ac.uk/pdbsum/1xxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xxu ProSAT], [https://www.topsan.org/Proteins/TBSGC/1xxu TOPSAN]</span></td></tr> | |
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- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/AHPE_MYCTU AHPE_MYCTU] Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. May represent an important antioxidant defense against cytotoxic peroxides, especially peroxynitrite, which can be formed by activated macrophages during infection.<ref>PMID:19737009</ref> <ref>PMID:24379404</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: | + | [[Category: Mycobacterium tuberculosis]] |
- | [[Category: Baker | + | [[Category: Baker EN]] |
- | [[Category: Hung | + | [[Category: Hung LW]] |
- | [[Category: Kim | + | [[Category: Kim CY]] |
- | [[Category: Kim | + | [[Category: Kim MY]] |
- | [[Category: Lekin | + | [[Category: Lekin T]] |
- | [[Category: Li | + | [[Category: Li S]] |
- | [[Category: Lott | + | [[Category: Lott JS]] |
- | [[Category: Peterson | + | [[Category: Peterson NA]] |
- | [[Category: Segelke | + | [[Category: Segelke BW]] |
- | + | [[Category: Yu M]] | |
- | [[Category: Yu | + | |
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Current revision
Crystal Structure of AhpE from Mycrobacterium tuberculosis, a 1-Cys peroxiredoxin
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Categories: Large Structures | Mycobacterium tuberculosis | Baker EN | Hung LW | Kim CY | Kim MY | Lekin T | Li S | Lott JS | Peterson NA | Segelke BW | Yu M