1xxu

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Current revision (08:09, 25 October 2023) (edit) (undo)
 
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<StructureSection load='1xxu' size='340' side='right'caption='[[1xxu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1xxu' size='340' side='right'caption='[[1xxu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1xxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XXU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1xxu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XXU FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xvw|1xvw]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv2238c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxu OCA], [https://pdbe.org/1xxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xxu RCSB], [https://www.ebi.ac.uk/pdbsum/1xxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xxu ProSAT], [https://www.topsan.org/Proteins/TBSGC/1xxu TOPSAN]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxu OCA], [http://pdbe.org/1xxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xxu RCSB], [http://www.ebi.ac.uk/pdbsum/1xxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xxu ProSAT], [http://www.topsan.org/Proteins/TBSGC/1xxu TOPSAN]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AHPE_MYCTU AHPE_MYCTU] Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. May represent an important antioxidant defense against cytotoxic peroxides, especially peroxynitrite, which can be formed by activated macrophages during infection.<ref>PMID:19737009</ref> <ref>PMID:24379404</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Peroxidase]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Baker, E N]]
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[[Category: Baker EN]]
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[[Category: Hung, L W]]
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[[Category: Hung LW]]
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[[Category: Kim, C Y]]
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[[Category: Kim CY]]
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[[Category: Kim, M Y]]
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[[Category: Kim MY]]
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[[Category: Lekin, T]]
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[[Category: Lekin T]]
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[[Category: Li, S]]
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[[Category: Li S]]
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[[Category: Lott, J S]]
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[[Category: Lott JS]]
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[[Category: Peterson, N A]]
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[[Category: Peterson NA]]
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[[Category: Segelke, B W]]
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[[Category: Segelke BW]]
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[[Category: Structural genomic]]
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[[Category: Yu M]]
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[[Category: Yu, M]]
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[[Category: 1-cys peroxiredoxin]]
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[[Category: Oxidoreductase]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Tbsgc]]
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[[Category: Thioredoxin fold]]
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Current revision

Crystal Structure of AhpE from Mycrobacterium tuberculosis, a 1-Cys peroxiredoxin

PDB ID 1xxu

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