1nql

(Difference between revisions)

Revision as of 23:51, 2 May 2008

Image:1nql.jpg

Template:STRUCTURE 1nql

Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.

1 Overview
2 Disease
3 About this Structure
4 Reference

Overview

Epidermal growth factor (EGF) receptor is the prototype of the ErbB (HER) family receptor tyrosine kinases (RTKs), which regulate cell growth and differentiation and are implicated in many human cancers. EGF activates its receptor by inducing dimerization of the 621 amino acid EGF receptor extracellular region. We describe the 2.8 A resolution crystal structure of this entire extracellular region (sEGFR) in an unactivated state. The structure reveals an autoinhibited configuration, where the dimerization interface recently identified in activated sEGFR structures is completely occluded by intramolecular interactions. To activate the receptor, EGF binding must promote a large domain rearrangement that exposes this dimerization interface. This contrasts starkly with other RTK activation mechanisms and suggests new approaches for designing ErbB receptor antagonists.

Disease

Known disease associated with this structure: Hypomagnesemia 4, renal OMIM:[131530]

About this Structure

1NQL is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization., Ferguson KM, Berger MB, Mendrola JM, Cho HS, Leahy DJ, Lemmon MA, Mol Cell. 2003 Feb;11(2):507-17. PMID:12620237 Page seeded by OCA on Sat May 3 02:51:50 2008

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OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nql"

@@ Line 1: / Line 1: @@
 [[Image:1nql.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1nql |SIZE=350|CAPTION= <scene name='initialview01'>1nql</scene>, resolution 2.80&Aring;
+The line below this paragraph, containing "STRUCTURE_1nql", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= EGF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
-|DOMAIN=
+{{STRUCTURE_1nql|  PDB=1nql  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nql OCA], [http://www.ebi.ac.uk/pdbsum/1nql PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nql RCSB]</span>
-}}
 '''Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.'''
@@ Line 30: / Line 27: @@
 [[Category: Ferguson, K M.]]
 [[Category: Lemmon, M A.]]
-[[Category: auto-inhibition]]
+[[Category: Auto-inhibition]]
-[[Category: cell surface receptor]]
+[[Category: Cell surface receptor]]
-[[Category: endosomal]]
+[[Category: Endosomal]]
-[[Category: glycoprotein]]
+[[Category: Glycoprotein]]
-[[Category: growth factor]]
+[[Category: Growth factor]]
-[[Category: tyrosine kinase]]
+[[Category: Tyrosine kinase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:51:50 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:34:10 2008''