1zu4

From Proteopedia

(Difference between revisions)

Current revision

Crystal structure of FtsY from Mycoplasma mycoides- space group P21212

Structural highlights

1zu4 is a 1 chain structure with sequence from Mycoplasma mycoides. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.95Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FTSY_MYCMS Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).[HAMAP-Rule:MF_00920]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The prokaryotic signal recognition particle Ffh and its receptor FtsY allow targeting of proteins into or across the plasma membrane. The targeting process is GTP dependent and the two proteins constitute a distinct GTPase family. The receptor FtsY is composed of A and NG domains where the NG's GTPase domain plays a critical role in the targeting process. In this study, we describe two X-ray structures determined independently of each other of the NG domain of FtsY from Mycoplasma mycoides (MmFtsY). The two structures are markedly different in three of the nucleotide-binding segments, GI (P-loop), GII, and GIII, making only one of the structures compatible with nucleotide binding. Interestingly, the two distinct conformations of the nucleotide-binding segments of MmFtsY are similar to the apo- and ADP-loaded forms of certain ATPases. The structure of the extended interface between the A and NG domains of MmFtsY provides new insights into the role of the A domain for phospholipid interaction.

Conformational variability of the GTPase domain of the signal recognition particle receptor FtsY.,Gariani T, Samuelsson T, Sauer-Eriksson AE J Struct Biol. 2006 Jan;153(1):85-96. Epub 2005 Nov 30. PMID:16343944^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Gariani T, Samuelsson T, Sauer-Eriksson AE. Conformational variability of the GTPase domain of the signal recognition particle receptor FtsY. J Struct Biol. 2006 Jan;153(1):85-96. Epub 2005 Nov 30. PMID:16343944 doi:http://dx.doi.org/10.1016/j.jsb.2005.10.003

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zu4"

Categories: Large Structures | Mycoplasma mycoides | Gariani T | Samuelsson T | Sauer-Eriksson AE

@@ Line 3: / Line 3: @@
 <StructureSection load='1zu4' size='340' side='right'caption='[[1zu4]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1zu4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"asterococcus_mycoides"_borrel_et_al._1910 "asterococcus mycoides" borrel et al. 1910]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZU4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1zu4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplasma_mycoides Mycoplasma mycoides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZU4 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zu5|1zu5]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zu4 OCA], [https://pdbe.org/1zu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zu4 RCSB], [https://www.ebi.ac.uk/pdbsum/1zu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zu4 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/FTSY_MYCMS FTSY_MYCMS] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).[HAMAP-Rule:MF_00920]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 34: / Line 36: @@
 __TOC__
 </StructureSection>
-[[Category: Asterococcus mycoides borrel et al. 1910]]
 [[Category: Large Structures]]
-[[Category: Gariani, T]]
+[[Category: Mycoplasma mycoides]]
-[[Category: Samuelsson, T]]
+[[Category: Gariani T]]
-[[Category: Sauer-Eriksson, A E]]
+[[Category: Samuelsson T]]
-[[Category: Ftsy]]
+[[Category: Sauer-Eriksson AE]]
-[[Category: Gtpase]]
-[[Category: Protein transport]]
-[[Category: Receptor]]
-[[Category: Signal recognition particle]]
-[[Category: Srp]]

1zu4

From Proteopedia

Current revision

Crystal structure of FtsY from Mycoplasma mycoides- space group P21212

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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