2ef1
From Proteopedia
(Difference between revisions)
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<StructureSection load='2ef1' size='340' side='right'caption='[[2ef1]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='2ef1' size='340' side='right'caption='[[2ef1]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ef1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2ef1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2df1 2df1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EF1 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ef1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef1 OCA], [https://pdbe.org/2ef1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ef1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ef1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ef1 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ef1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef1 OCA], [https://pdbe.org/2ef1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ef1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ef1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ef1 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Hara-Yokoyama | + | [[Category: Hara-Yokoyama M]] |
| - | [[Category: Katada | + | [[Category: Katada T]] |
| - | [[Category: Kukimoto-Niino | + | [[Category: Kukimoto-Niino M]] |
| - | [[Category: Murayama | + | [[Category: Murayama K]] |
| - | [[Category: Nureki | + | [[Category: Nureki O]] |
| - | + | [[Category: Shirouzu M]] | |
| - | [[Category: Shirouzu | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Crystal structure of the extracellular domain of human CD38
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