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2ef6

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Current revision (08:39, 25 October 2023) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [https://pdbe.org/2ef6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ef6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [https://pdbe.org/2ef6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ef6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL]] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>
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[https://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Canavalia gladiata]]
[[Category: Canavalia gladiata]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Azevedo, W F.de]]
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[[Category: Benevides RG]]
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[[Category: Benevides, R G]]
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[[Category: Bezerra GA]]
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[[Category: Bezerra, G A]]
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[[Category: Cavada BS]]
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[[Category: Cavada, B S]]
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[[Category: Delatorre P]]
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[[Category: Delatorre, P]]
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[[Category: Moreno FBMB]]
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[[Category: Moreno, F B.M B]]
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[[Category: Oliveira TM]]
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[[Category: Oliveira, T M]]
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[[Category: Da Rocha BAM]]
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[[Category: Rocha, B A.M da]]
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[[Category: De Azevedo Jr WF]]
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[[Category: Souza, E P.de]]
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[[Category: De Souza EP]]
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[[Category: Dimannoside]]
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[[Category: Lectin]]
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[[Category: Plant protein]]
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[[Category: Seed]]
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Current revision

Canavalia gladiata lectin complexed with Man1-3Man-OMe

PDB ID 2ef6

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OCA

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