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2ew5

From Proteopedia

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Current revision (08:44, 25 October 2023) (edit) (undo)
 
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<StructureSection load='2ew5' size='340' side='right'caption='[[2ew5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2ew5' size='340' side='right'caption='[[2ew5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ew5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EW5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ew5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EW5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=Y12:4-{(1E)-3-OXO-3-[(2-PHENYLETHYL)AMINO]PROP-1-EN-1-YL}-1,2-PHENYLENE+DIACETATE'>Y12</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ew6|2ew6]], [[2ew7|2ew7]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=Y12:4-{(1E)-3-OXO-3-[(2-PHENYLETHYL)AMINO]PROP-1-EN-1-YL}-1,2-PHENYLENE+DIACETATE'>Y12</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ew5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ew5 OCA], [https://pdbe.org/2ew5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ew5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ew5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ew5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ew5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ew5 OCA], [https://pdbe.org/2ew5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ew5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ew5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ew5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/Q672W7_HELPX Q672W7_HELPX]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).[HAMAP-Rule:MF_00163]
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[https://www.uniprot.org/uniprot/Q672W7_HELPX Q672W7_HELPX] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).[HAMAP-Rule:MF_00163]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 43504]]
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[[Category: Helicobacter pylori]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Peptide deformylase]]
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[[Category: Cai J]]
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[[Category: Cai, J]]
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[[Category: Cobalt helicobacter pylori peptide deformylase]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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Current revision

Structure of Helicobacter Pylori peptide deformylase in complex with inhibitor

PDB ID 2ew5

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