2g5x

<table><tr><td colspan='2'>[[2g5x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lychnis_chalcedonica Lychnis chalcedonica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G5X FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rl0|1rl0]], [[1wuc|1wuc]]</div></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>

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== Publication Abstract from PubMed ==

Ribosome-inactivating proteins (RIPs) similar to those already known (Stirpe &amp; Barbieri (1986) FEBS Lett. 195, 1-8) were purified from the seeds of Asparagus officinalis (two proteins, asparin 1 and 2), of Citrullus colocynthis (two proteins, colocin 1 and 2), of Lychnis chalcedonica (lychnin) and of Manihot palmata (mapalmin), from the roots of Phytolacca americana (pokeweed antiviral protein from roots, PAP-R) and from the leaves of Bryonia dioica (bryodin-L). The two latter proteins can be considered as isoforms, respectively, of previously purified PAP, from the leaves of P. americana, and of bryodin-R, from the roots of B. dioica. All proteins have an Mr at approx, 30,000, and an alkaline isoelectric point. Bryodin-L, colocins, lychnin and mapalmin are glycoproteins. All RIPs inhibit protein synthesis by a rabbit reticulocyte lysate and phenylalanine polymerization by isolated ribosomes and alter rRNA in a similar manner as the A-chain of ricin and related toxins (Endo et al. (1987) J. Biol. Chem. 262, 5908-5912).

Purification and properties of new ribosome-inactivating proteins with RNA N-glycosidase activity.,Bolognesi A, Barbieri L, Abbondanza A, Falasca AI, Carnicelli D, Battelli MG, Stirpe F Biochim Biophys Acta. 1990 Nov 30;1087(3):293-302. PMID:2248976<ref>PMID:2248976</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2g5x" style="background-color:#fffaf0;"></div>

*[[Ribosome inactivating protein|Ribosome inactivating protein]]

[[Category: Lychnis chalcedonica]]

[[Category: RRNA N-glycosylase]]

[[Category: Bolognesi, A]]

[[Category: Falini, G]]

[[Category: Fermani, S]]

[[Category: Polito, L]]

[[Category: Ripamonti, A]]

[[Category: Stirpe, F]]

[[Category: Tosi, G]]

[[Category: Hydrolase]]