2os3

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Current revision (08:58, 25 October 2023) (edit) (undo)
 
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<StructureSection load='2os3' size='340' side='right'caption='[[2os3]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
<StructureSection load='2os3' size='340' side='right'caption='[[2os3]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2os3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_(serotype_1_/_m1_gas) Streptococcus pyogenes (serotype 1 / m1 gas)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OS3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2os3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_M1_GAS Streptococcus pyogenes M1 GAS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OS3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2os0|2os0]], [[2os1|2os1]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">def ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160490 Streptococcus pyogenes (serotype 1 / M1 GAS)])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2os3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os3 OCA], [https://pdbe.org/2os3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2os3 RCSB], [https://www.ebi.ac.uk/pdbsum/2os3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2os3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2os3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os3 OCA], [https://pdbe.org/2os3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2os3 RCSB], [https://www.ebi.ac.uk/pdbsum/2os3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2os3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/DEF_STRP1 DEF_STRP1]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
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[https://www.uniprot.org/uniprot/DEF_STRP1 DEF_STRP1] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Peptide deformylase]]
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[[Category: Streptococcus pyogenes M1 GAS]]
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[[Category: Choi, K]]
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[[Category: Choi K]]
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[[Category: Kim, E E]]
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[[Category: Kim EE]]
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[[Category: Kim, K H]]
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[[Category: Kim K-H]]
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[[Category: Lee, H K]]
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[[Category: Lee HK]]
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[[Category: Moon, J H]]
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[[Category: Moon JH]]
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[[Category: Parh, H S]]
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[[Category: Parh HS]]
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[[Category: Hydrolase]]
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[[Category: Pdf]]
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Current revision

Structures of actinonin bound peptide deformylases from E. faecalis and S. pyogenes

PDB ID 2os3

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