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1nsh

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[[Image:1nsh.gif|left|200px]]
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{{Structure
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|GENE= S100A11 OR S100C OR PCALG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nsh OCA], [http://www.ebi.ac.uk/pdbsum/1nsh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nsh RCSB]</span>
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'''Solution Structure of Rabbit apo-S100A11 (19 models)'''
'''Solution Structure of Rabbit apo-S100A11 (19 models)'''
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[[Category: Shaw, G S.]]
[[Category: Shaw, G S.]]
[[Category: Walsh, M P.]]
[[Category: Walsh, M P.]]
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[[Category: calcium-binding protein]]
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[[Category: Calcium-binding protein]]
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[[Category: ef hand]]
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[[Category: Ef hand]]
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[[Category: helix-loop-helix]]
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[[Category: Helix-loop-helix]]
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[[Category: s100a11]]
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[[Category: S100a11]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:55:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:34:50 2008''
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Revision as of 23:55, 2 May 2008

Image:1nsh.gif

Template:STRUCTURE 1nsh

Solution Structure of Rabbit apo-S100A11 (19 models)


Overview

S100A11 is a homodimeric EF-hand calcium binding protein that undergoes a calcium-induced conformational change and interacts with the phospholipid binding protein annexin I to coordinate membrane association. In this work, the solution structure of apo-S100A11 has been determined by NMR spectroscopy to uncover the details of its calcium-induced structural change. Apo-S100A11 forms a tight globular structure having a near antiparallel orientation of helices III and IV in calcium binding site II. Further, helices I and IV, and I and I', form a more closed arrangement than observed in other apo-S100 proteins. This helix arrangement in apo-S100A11 partially buries residues in helices I (P3, E11, A15), III (V55, R58, M59), and IV (A86, C87, S90) and the linker (A45, F46), which are required for interaction with annexin I in the calcium-bound state. In apo-S100A11, this results in a "masked" binding surface that prevents annexin I binding but is uncovered upon calcium binding.

About this Structure

1NSH is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Unmasking the annexin I interaction from the structure of Apo-S100A11., Dempsey AC, Walsh MP, Shaw GS, Structure. 2003 Jul;11(7):887-97. PMID:12842051 Page seeded by OCA on Sat May 3 02:55:26 2008

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