2yxj

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Current revision (09:10, 25 October 2023) (edit) (undo)
 
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<StructureSection load='2yxj' size='340' side='right'caption='[[2yxj]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2yxj' size='340' side='right'caption='[[2yxj]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yxj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YXJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yxj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YXJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=N3C:4-{4-[(4-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>N3C</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2o2m|2o2m]], [[2o2n|2o2n]], [[1ysg|1ysg]], [[1ysi|1ysi]], [[1ysn|1ysn]], [[2o1y|2o1y]], [[1pq1|1pq1]], [[1pq0|1pq0]], [[1maz|1maz]], [[1af3|1af3]], [[1r2d|1r2d]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=N3C:4-{4-[(4-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>N3C</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Bcl-xL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxj OCA], [https://pdbe.org/2yxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yxj RCSB], [https://www.ebi.ac.uk/pdbsum/2yxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yxj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxj OCA], [https://pdbe.org/2yxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yxj RCSB], [https://www.ebi.ac.uk/pdbsum/2yxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yxj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
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[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Colman, P M]]
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[[Category: Colman PM]]
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[[Category: Czabotar, P E]]
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[[Category: Czabotar PE]]
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[[Category: Deshayes, K]]
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[[Category: Deshayes K]]
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[[Category: Fairlie, W D]]
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[[Category: Fairlie WD]]
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[[Category: Lee, E F]]
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[[Category: Lee EF]]
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[[Category: Smith, B J]]
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[[Category: Smith BJ]]
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[[Category: Zobel, K]]
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[[Category: Zobel K]]
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[[Category: Apoptosis]]
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[[Category: Cancer therapeutic]]
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Current revision

Crystal structure of Bcl-xL in complex with ABT-737

PDB ID 2yxj

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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