1nt0

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[[Image:1nt0.gif|left|200px]]
[[Image:1nt0.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1nt0", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=AHB:BETA-HYDROXYASPARAGINE'>AHB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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{{STRUCTURE_1nt0| PDB=1nt0 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nt0 OCA], [http://www.ebi.ac.uk/pdbsum/1nt0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nt0 RCSB]</span>
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'''Crystal structure of the CUB1-EGF-CUB2 region of MASP2'''
'''Crystal structure of the CUB1-EGF-CUB2 region of MASP2'''
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[[Category: Wallis, R.]]
[[Category: Wallis, R.]]
[[Category: Weis, W I.]]
[[Category: Weis, W I.]]
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[[Category: cub domain]]
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[[Category: Cub domain]]
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[[Category: egf like domain.]]
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[[Category: Egf like domain.]]
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[[Category: mannose-binding protein]]
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[[Category: Mannose-binding protein]]
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[[Category: masp]]
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[[Category: Masp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:56:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:35:06 2008''
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Revision as of 23:56, 2 May 2008

Image:1nt0.gif

Template:STRUCTURE 1nt0

Crystal structure of the CUB1-EGF-CUB2 region of MASP2


Overview

Serum mannose-binding proteins (MBPs) are C-type lectins that recognize cell surface carbohydrate structures on pathogens, and trigger killing of these targets by activating the complement pathway. MBPs circulate as a complex with MBP-associated serine proteases (MASPs), which become activated upon engagement of a target cell surface. The minimal functional unit for complement activation is a MASP homodimer bound to two MBP trimeric subunits. MASPs have a modular structure consisting of an N-terminal CUB domain, a Ca(2+)-binding EGF-like domain, a second CUB domain, two complement control protein modules and a C-terminal serine protease domain. The CUB1-EGF-CUB2 region mediates homodimerization and binding to MBP. The crystal structure of the MASP-2 CUB1-EGF-CUB2 dimer reveals an elongated structure with a prominent concave surface that is proposed to be the MBP-binding site. A model of the full six-domain structure and its interaction with MBPs suggests mechanisms by which binding to a target cell transmits conformational changes from MBP to MASP that allow activation of its protease activity.

About this Structure

1NT0 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2., Feinberg H, Uitdehaag JC, Davies JM, Wallis R, Drickamer K, Weis WI, EMBO J. 2003 May 15;22(10):2348-59. PMID:12743029 Page seeded by OCA on Sat May 3 02:56:35 2008

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