1nt2

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[[Image:1nt2.jpg|left|200px]]
[[Image:1nt2.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1nt2", creates the "Structure Box" on the page.
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|GENE= AF2087 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 Archaeoglobus fulgidus]), AF2088 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 Archaeoglobus fulgidus])
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{{STRUCTURE_1nt2| PDB=1nt2 | SCENE= }}
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|RELATEDENTRY=[[1fbn|1FBN]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nt2 OCA], [http://www.ebi.ac.uk/pdbsum/1nt2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nt2 RCSB]</span>
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'''CRYSTAL STRUCTURE OF FIBRILLARIN/NOP5P COMPLEX'''
'''CRYSTAL STRUCTURE OF FIBRILLARIN/NOP5P COMPLEX'''
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[[Category: Palmer, J R.]]
[[Category: Palmer, J R.]]
[[Category: Rashid, R.]]
[[Category: Rashid, R.]]
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[[Category: ademet]]
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[[Category: Ademet]]
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[[Category: binding motif]]
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[[Category: Binding motif]]
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[[Category: coiled coil]]
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[[Category: Coiled coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:56:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:35:05 2008''
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Revision as of 23:56, 2 May 2008

Image:1nt2.jpg

Template:STRUCTURE 1nt2

CRYSTAL STRUCTURE OF FIBRILLARIN/NOP5P COMPLEX


Overview

Nop56p and Nop58p are two core proteins of the box C/D snoRNPs that interact concurrently with fibrillarin and snoRNAs to function in enzyme assembly and catalysis. Here we report the 2.9 A resolution co-crystal structure of an archaeal homolog of Nop56p/Nop58p, Nop5p, in complex with fibrillarin from Archaeoglobus fulgidus (AF) and the methyl donor S-adenosyl-L-methionine. The N-terminal domain of Nop5p forms a complementary surface to fibrillarin that serves to anchor the catalytic subunit and to stabilize cofactor binding. A coiled coil in Nop5p mediates dimerization of two fibrillarin-Nop5p heterodimers for optimal interactions with bipartite box C/D RNAs. Structural analysis and complementary biochemical data demonstrate that the conserved C-terminal domain of Nop5p harbors RNA-binding sites. A model of box C/D snoRNP assembly is proposed based on the presented structural and biochemical data.

About this Structure

1NT2 is a Protein complex structure of sequences from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

Structure and function of archaeal box C/D sRNP core proteins., Aittaleb M, Rashid R, Chen Q, Palmer JR, Daniels CJ, Li H, Nat Struct Biol. 2003 Apr;10(4):256-63. PMID:12598892 Page seeded by OCA on Sat May 3 02:56:39 2008

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