8dgy
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8dgy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DGY FirstGlance]. <br> | <table><tr><td colspan='2'>[[8dgy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DGY FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=S9U:[(1~{R},2~{R})-2-(cyclohexylmethyl)cyclopropyl]methyl+~{N}-[(2~{S})-1-[[(1~{S},2~{S})-1-[bis(oxidanyl)-oxidanylidene-$l^{5}-sulfanyl]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamate'>S9U</scene>, <scene name='pdbligand=SD6:[(1~{R},2~{R})-2-(cyclohexylmethyl)cyclopropyl]methyl+~{N}-[(2~{S})-1-[[(1~{R},2~{S})-1-[bis(oxidanyl)-oxidanylidene-$l^{5}-sulfanyl]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamate'>SD6</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=S9U:[(1~{R},2~{R})-2-(cyclohexylmethyl)cyclopropyl]methyl+~{N}-[(2~{S})-1-[[(1~{S},2~{S})-1-[bis(oxidanyl)-oxidanylidene-$l^{5}-sulfanyl]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamate'>S9U</scene>, <scene name='pdbligand=SD6:[(1~{R},2~{R})-2-(cyclohexylmethyl)cyclopropyl]methyl+~{N}-[(2~{S})-1-[[(1~{R},2~{S})-1-[bis(oxidanyl)-oxidanylidene-$l^{5}-sulfanyl]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamate'>SD6</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dgy OCA], [https://pdbe.org/8dgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dgy RCSB], [https://www.ebi.ac.uk/pdbsum/8dgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dgy ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dgy OCA], [https://pdbe.org/8dgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dgy RCSB], [https://www.ebi.ac.uk/pdbsum/8dgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dgy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Revision as of 10:09, 25 October 2023
Structure of MERS 3CL protease in complex with the cyclopropane based inhibitor 16d (high resolution)
| |||||||||||
