8ea6

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[8ea6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EA6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[8ea6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EA6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VMB:N-{(1S)-2-(dimethylamino)-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4-(trifluoromethyl)[1,1-biphenyl]-2-carboxamide'>VMB</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VMB:N-{(1S)-2-(dimethylamino)-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4-(trifluoromethyl)[1,1-biphenyl]-2-carboxamide'>VMB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ea6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ea6 OCA], [https://pdbe.org/8ea6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ea6 RCSB], [https://www.ebi.ac.uk/pdbsum/8ea6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ea6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ea6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ea6 OCA], [https://pdbe.org/8ea6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ea6 RCSB], [https://www.ebi.ac.uk/pdbsum/8ea6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ea6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/NKG2D_HUMAN NKG2D_HUMAN] Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.
[https://www.uniprot.org/uniprot/NKG2D_HUMAN NKG2D_HUMAN] Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.
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==See Also==
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*[[NK cell receptor|NK cell receptor]]
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</StructureSection>
</StructureSection>

Revision as of 10:19, 25 October 2023

NKG2D complexed with inhibitor 3e

PDB ID 8ea6

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