8edi

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[8edi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EDI FirstGlance]. <br>
<table><tr><td colspan='2'>[[8edi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EDI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=UAP:4-DEOXY-2-O-SULFO-ALPHA-L-THREO-HEX-4-ENOPYRANURONIC+ACID'>UAP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=UAP:4-DEOXY-2-O-SULFO-ALPHA-L-THREO-HEX-4-ENOPYRANURONIC+ACID'>UAP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8edi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8edi OCA], [https://pdbe.org/8edi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8edi RCSB], [https://www.ebi.ac.uk/pdbsum/8edi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8edi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8edi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8edi OCA], [https://pdbe.org/8edi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8edi RCSB], [https://www.ebi.ac.uk/pdbsum/8edi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8edi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/UNC5_CAEEL UNC5_CAEEL] Receptor for netrin (unc-6) required for axon guidance (PubMed:8332188, PubMed:11454756). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:1384987, PubMed:8332188, PubMed:11454756, PubMed:9473333). Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors (PubMed:11454756, PubMed:9473333). Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced-10/Rac, ced-12/ELMO and mig-2/RhoG (PubMed:10631179, PubMed:26292279, PubMed:17716643).<ref>PMID:10631179</ref> <ref>PMID:11454756</ref> <ref>PMID:1384987</ref> <ref>PMID:17716643</ref> <ref>PMID:26292279</ref> <ref>PMID:8332188</ref> <ref>PMID:9473333</ref>
[https://www.uniprot.org/uniprot/UNC5_CAEEL UNC5_CAEEL] Receptor for netrin (unc-6) required for axon guidance (PubMed:8332188, PubMed:11454756). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:1384987, PubMed:8332188, PubMed:11454756, PubMed:9473333). Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors (PubMed:11454756, PubMed:9473333). Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced-10/Rac, ced-12/ELMO and mig-2/RhoG (PubMed:10631179, PubMed:26292279, PubMed:17716643).<ref>PMID:10631179</ref> <ref>PMID:11454756</ref> <ref>PMID:1384987</ref> <ref>PMID:17716643</ref> <ref>PMID:26292279</ref> <ref>PMID:8332188</ref> <ref>PMID:9473333</ref>
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==See Also==
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*[[Netrin receptor|Netrin receptor]]
== References ==
== References ==
<references/>
<references/>

Revision as of 10:20, 25 October 2023

Structure of C. elegans UNC-5 IG 1+2 Domains bound to Heparin dp4

PDB ID 8edi

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