5lyh

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Current revision (10:56, 25 October 2023) (edit) (undo)
 
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==Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor H10==
==Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor H10==
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<StructureSection load='5lyh' size='340' side='right' caption='[[5lyh]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
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<StructureSection load='5lyh' size='340' side='right'caption='[[5lyh]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lyh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LYH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LYH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lyh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LYH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7B8:3-[2-[4-[2-[[4-[(3-AMINOCARBONYLPHENYL)AMINO]-4-OXIDANYLIDENE-BUTANOYL]AMINO]ETHYL]-1,2,3-TRIAZOL-1-YL]ETHYLSULFAMOYL]BENZOIC+ACID'>7B8</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5lxp|5lxp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7B8:3-[2-[4-[2-[[4-[(3-AMINOCARBONYLPHENYL)AMINO]-4-OXIDANYLIDENE-BUTANOYL]AMINO]ETHYL]-1,2,3-TRIAZOL-1-YL]ETHYLSULFAMOYL]BENZOIC+ACID'>7B8</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PARP14, BAL2, KIAA1268 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lyh OCA], [https://pdbe.org/5lyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lyh RCSB], [https://www.ebi.ac.uk/pdbsum/5lyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lyh ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lyh OCA], [http://pdbe.org/5lyh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lyh RCSB], [http://www.ebi.ac.uk/pdbsum/5lyh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lyh ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PAR14_HUMAN PAR14_HUMAN]] Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.
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[https://www.uniprot.org/uniprot/PAR14_HUMAN PAR14_HUMAN] Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5lyh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5lyh" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Karlberg, T]]
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[[Category: Large Structures]]
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[[Category: Schuler, H]]
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[[Category: Karlberg T]]
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[[Category: Thorsell, A G]]
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[[Category: Schuler H]]
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[[Category: Adp-ribosylation]]
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[[Category: Thorsell AG]]
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[[Category: Inhibitor complex]]
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[[Category: Transferase]]
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[[Category: Transferase domain]]
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Current revision

Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor H10

PDB ID 5lyh

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