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8afw

From Proteopedia

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m (Protected "8afw" [edit=sysop:move=sysop])
Current revision (13:02, 1 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8afw is ON HOLD until Paper Publication
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==Tube assembly of Atg18-WT==
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<StructureSection load='8afw' size='340' side='right'caption='[[8afw]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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Authors: Mann, D., Fromm, S., Martinez-Sanchez, A., Gopaldass, N., Mayer, A., Sachse, C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8afw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AFW FirstGlance]. <br>
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Description: Tube assembly of Atg18-WT
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8afw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8afw OCA], [https://pdbe.org/8afw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8afw RCSB], [https://www.ebi.ac.uk/pdbsum/8afw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8afw ProSAT]</span></td></tr>
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[[Category: Mann, D]]
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</table>
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[[Category: Sachse, C]]
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== Function ==
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[[Category: Gopaldass, N]]
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[https://www.uniprot.org/uniprot/ATG18_YEAST ATG18_YEAST] The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). May negatively regulate FAB1 activity by sequestering or masking VAC7 from FAB1. Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication. With ATG2, protects ATG8 from ATG4-mediated cleavage.<ref>PMID:11470404</ref> <ref>PMID:11536337</ref> <ref>PMID:11707261</ref> <ref>PMID:11739783</ref> <ref>PMID:14723849</ref> <ref>PMID:15155809</ref> <ref>PMID:15194695</ref> <ref>PMID:16876790</ref> <ref>PMID:17699591</ref> <ref>PMID:18586673</ref> <ref>PMID:18769150</ref> <ref>PMID:19037259</ref> <ref>PMID:20154084</ref> <ref>PMID:22108003</ref> <ref>PMID:22728243</ref> <ref>PMID:22787281</ref> <ref>PMID:24905091</ref>
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[[Category: Mayer, A]]
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== References ==
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[[Category: Fromm, S]]
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<references/>
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[[Category: Martinez-Sanchez, A]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Fromm S]]
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[[Category: Gopaldass N]]
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[[Category: Mann D]]
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[[Category: Martinez-Sanchez A]]
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[[Category: Mayer A]]
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[[Category: Sachse C]]

Current revision

Tube assembly of Atg18-WT

PDB ID 8afw

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OCA

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